Blood cultures and diagnosis of sepsisMonday, May 09, 2011, 12:30 - 13:30
Predictive value of soluble urokinase plasminogen activator factor in ventilator-associated pneumonia and sepsisA. Savva, C. Routsi, G. Dimopoulos, A. Antonopoulou, M. Georgitsi, E.J. Giamarellos-Bourboulis* (Athens, GR)
Objectives: Urokinase plasminogen activator (uPAR) is a receptor expressed on neutrophils and NK cells. The role of its soluble form, namely suPAR, as a predictor of sepsis outcome was investigated..
Methods: Blood samples were collected from 180 patients with ventilator-associated pneumonia (VAP) and sepsis for seven consecutive days; 47 with sepsis; 49 with severe sepsis; and 84 with septic shock. suPAR was measured in serum by an enzyme immunoassay and PCT by an immuno-time-resolved amplified cryptate assay.
Results: ROC analysis of day 1 measurements for prediction of death is shown in the Figure. Mean suPAR of days 1, 2, 3, 4, 5, 6 and 7 among survivors was 9.1, 10.5, 10.7, 10.6, 10.5, 11.2 and 10.9 ng/ml respectively; respective values among non-survivors were 14.1, 14.7, 15.1, 16.1, 18.1, 19.3 and 19.3 ng/ml.
Conclusion: suPAR is a strong predictor of unfavorable outcome in VAP and sepsis probably superior than PCT. Serum concentrations remain constantly elevated among non-survivors.