Acinetobacter baumanniiSaturday, May 07, 2011, 15:30 - 16:30Acinetobacter baumanni in Italian hospitals: results from a retrospective data analysis from the Micronet Network laboratoriesF. D Ancona*, A. Sisto, A. Raglio, M. Meledandri, A. Rocchetti and the Micronet Network participants
Acinetobacter baumannii is a pathogen frequently isolated in hospital that can survive for long period with different environmental condition. This Gram Negative pathogen can cause outbreaks with clinical pictures of sepsis, pneumonias, urinary and wound infections . Rarely it can cause meningitis. It can be responsible of colonization in hospitalised patients. Patients in intensive care units and surgeries are often affected by this infection with an increased mortality.
In order to evaluate the circulation of this pathogen and describe the phenotypic resistance to antimicrobial drugs, we conducted a retrospective descriptive analysis of the infections caused by A. baumannii, A. calcoaceticus complex and Acinetobacter spp from 1st January 2010 to 30th June 2010 in 22 Italian hospitals participant to Italian Micronet Network the largest nation-wide lab surveillance system.
The total number of ordinary hospitalization days in participating hospitals is 2,012,521. The total number of bed in the hospitals included in the study is 14066.
586 A. baumanniI (considering A. calcoaceticus complex, Acinetobacter spp and A. baumannii) were isolated by culture (isolates from the same patients before 30 days were excluded) .
The range by hospital was 0 to 80 isolates (mean 25, median 20) . The most frequent specimen types of first isolation were not protected respiratory specimens (n: 254, 43.3%), Urine (n: 92, 15.7%), protected respiratory specimens (n:63, 10.8%), blood culture (n:38, 6.5%)
272 were isolated from Intensive Care Units (46.4%), 57 (9.7%) from surgeries, 180 (30.7 %) from medicine ward.
Resistance to imipenem (539 samplings), meropenem (421), ampicillin sulbactam (97) and ceftazidime (574) were respectively 73.5%, 72.9%, 30.9%, 77.7%
307 (79.3%) of 387 isolates were non-susceptible both to imipenem and meropenem. Considering the percentage of circulating multiresistant A.baumanni circulating in hospital, it is a priority to activate control measure in the hospitals to avoid outbreaks that, especially in ICU where it can cause an excess of mortality. Surveillance of this events and monitoring of the antimicrobial resistance should be taken in consideration at national and local level.
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