Young Scientific Investigators’ Session 2Wednesday, October 02, 2013, 17:00 - 17:12
Brain atrophy in radiologically isolated syndrome (RIS)J. Rojas, L. Patrucco, J. Miguez, E. Cristiano (Buenos Aires, AR)
MRI lesions suggestive of multiple sclerosis (MS) in the absence of a clinical scenario is a condition named ‘‘radiologically isolated syndrome’’ (RIS). Scarce data exists about brain atrophy this condition. The aim of this study was to compare brain atrophy in RIS, in clinically isolated syndrome (CIS) and a healthy control sample
Methods: patients with RIS were included prospectively during June 2009 to June 2012. CIS patients (with less than a year of disease onset) and healthy volunteers matched by age and gender and included during the same period of time were used as control groups. An automated analysis tool, SIENAX, was used to obtain total brain volume (TBV), gray matter volume (GMV) and white matter volume (WMV). K-Wallis test was used to analyze the data.
Results: 12 RIS patients, 43 CIS patients and 29 healthy controls were included. Mean age for RIS was 30 ± 5.4 years vs. 34± 7 in CIS patients and 34.4 ± 9 in healthy controls (p=0.29). The TBV in RIS was 1.53 mm3 x 106, 1.51 x 106 in CIS and 1.64 x 106 in healthy controls (p= 0.12 vs. CIS and p=0.003 vs. healthy controls); the GMV in RIS was 0.56 x 106, 0.53 x 106 in CIS and 0.71 x 106 in healthy controls (p=0.2 vs. CIS and p=0.003 vs. healthy controls) and the WMV in RIS was 1 x 106, 0.98 in CIS and 1.12 x 106 in healthy controls (p=0.66 vs. CIS and p=0.12 vs. healthy controls). Conclusions: our study showed a decrease in brain volume of RIS patients compared with healthy controls similar to CIS patients. Future studies will help to confirm this finding.
Dr Cristiano has received honoraria in concept of scientific advisor from Novartis, Merck Serono, Biogen, Genzyme and Bayer.
Dr Patrucco has received has received honoraria in concept of scientific advisor from Merck Serono and Genzyme
Dr Rojas Has received honoraria in concept of scientifici advisor from Novartis.
Dr Miguez has nothing to disclosure