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Home - 04.10.2013 - Imaging


Friday, October 04, 2013, 15:30 - 17:00

Brain volume changes may predict conversion in radiologically isolated syndrome

L. Patucco, J. Rojas, J. Miguez, E. Cristiano (Buenos Aires, AR)

MRI lesions suggestive of multiple sclerosis (MS) in the absence of a clinical scenario is a condition named ‘‘radiologically isolated syndrome’’ (RIS). The objective was to determine predictive factors for conversion to a clinically isolated syndrome (CIS) or MS in subjects with RIS.
Methods: A retrospective review of RIS cases with at least 1 year of follow up was performed. Demographic, MRI findings (brain volumes and brain and spinal cord lesion load) and oligoclonal bands (OB) in CSF were analyzed as potential predictors for clinical progression.
Results: 12 subjects with RIS were included (mean follow up time 33.6 ± 12 months). 5 (42%) of them progressed clinically (3 to CIS, 2 to RRMS) over a mean time of 18 ± 5 months from the date of RIS identification. After adjusting for potential confounders, demographic, OB and lesion load in brain and spinal cord were not associated with progression of RIS. RIS subjects that progressed showed a decrease in white matter brain volume (0.9 x106 vs. 1.1x106, p=0.04), grey matter brain volume (0.5 x106 vs. 0.59x106, p=0.005) and total brain volume (1.51 x106 vs. 1.59x106 p=0.02) compared with RIS patients that did not.
Conclusion: we observed a decrease in brain volumes of patients with RIS that progressed to CIS or MS.
Brain atrophy would be a predictive factor for conversion in RIS if confirms by further studies.

Dr Cristiano has received honoraria in concept of scientific advisor from Novartis, Merck Serono, Biogen, Genzyme and Bayer. Dr Patrucco has received has received honoraria in concept of scientific advisor from Merck Serono and Genzyme Dr Rojas Has received honoraria in concept of scientifici advisor from Novartis. Dr Miguez has nothing to disclosure