23rd Congress of the European Committee for the Treatment and Research in Multiple Sclerosis (ECTRIMS)
&
12th Annual Conference of Rehabilitation in MS (RIMS)
11.10.2007 - 14.10.2007

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Home - 13.10.2007

Saturday, October 13, 2007
15:30 - 17:00

Poster topic 13

Immunology 2

		General
		CD4+ TCR V-beta specific overexpression in the thymus and peripheral blood of a patient with multiple sclerosis and myasthenia gravis	P 504
		B. Tackenberg, K. Gellert, K. Schlegel, M. Happel, A. Wellek, W.H. Oertel, N. Sommer (Marburg, Berlin-Lichtenberg, D)
		Heat shock protein 70 expression is deregulated in multiple sclerosis patients and can affect myelin antigen recognition	P 505
		H. Cwiklinska, M. Mycko, C.S. Raine, K. Selmaj (Lodz, PL; New York, USA)
		Autoantibody profiling in multiple sclerosis reveals novel antigenic candidates	P 506
		V. Somers, C. Govarts, K. Somers, R. Hupperts, R. Medaer, P. Stinissen (Diepenbeek, B; Maastricht, NL)
		Autoantibodies in multiple sclerosis: disease or therapy correlated?	P 507
		G. Iuliano, A. Ferruzzi, R. Napoletano, A. Esposito (Salerno, I)
		Increased PD-L1 expression and functional deficiencies in human plasmacytoid dendritic cells	P 509
		R. Lopez-Diego, L. Santos, D. Anderson, H. Weiner (Boston, USA)
		Cytokine regulation of cannabinoid receptors 1&2: a multiple sclerosis perspective	P 510
		L. Jean-Gilles, C.S. Constantinescu (Nottingham, UK)
		CD94/NKG2A molecules in CD8+ regulatory T-cells: differential expression and modulation during the course of multiple sclerosis	P 511
		J. Correale, A. Villa (Buenos Aires, AR)
		Low and dysregulated BDNF secretion from immune cells of relapsing-remitting MS patients is related to reduced neuroprotection	P 512
		D. Azoulay, N. Orshansky, A. Karni (Tel Aviv, IL)
		c-jun N-terminal kinase and T-cell apoptosis in relapsing-remitting multiple sclerosis	P 513
		C. Ferrandi, F. Richard, P. Tavano, V. Barbié, R. Furlan, G. Comi, M. Mariani, E. Hauben, G. Martino, P. Zaratin (Colleretto Giacosa, Milan, I)
		MIC molecules are expressed in multiple sclerosis plaques by different cell types and can be induced by sera from relapsing patients	P 514
		J. Villafani, P. Oliva-Nacarino, A. Tunon, S. Rodriguez-Rodero, A. Lopez-Vazquez, A. Astudillo, S. Gonzalez, C. Lahoz, C. Lopez-Larrea, J.L. Fernandez-Morera (Oviedo, E)
		Proteome analysis of cerebrospinal fluid in patients with multiple sclerosis	P 515
		H. Tumani, S. Süssmuth, J. Brettschneider, C. Palm, I. Guttman, V. Lehmensiek (Ulm, D)
		T-cells from multiple sclerosis patients recognise multiple epitopes on self-IgG from cerebrospinal fluid	P 516
		A. Karlsgot Hestvik, F. Vartdal, A. Brunsvik Fredriksen, K.M. Thompson, E. Østhagen Kvale, G. Skorstad, B. Bogen, T. Holmøy (Oslo, N)
		Cerebrospinal fluid: frequency of abnormal non-specific IgG measurements and novel specific myelin basic protein autoantibodies in a multiple sclerosis cohort from 1978 to 2007	P 517
		I. Catz, K.G. Warren (Edmonton, CAN)
		Serum autoantibodies to claudin domain containing 1 protein in Japanese patients with multiple sclerosis	P 518
		M. Minohara, T. Matsuoka, T. Matsushita, N. Kawamura, J. Kira (Fukuoka, JP)
		Va7.2-Ja33 mucosal-associated invariant T-cells accumulate in multiple sclerosis and CIDP lesions in contrast to a deficiency of Va24-JaQ NKT cells	P 519
		Z. Illes, T. Yamamura (Pecs, HUN; Tokyo, JP)
		Invariant TCR of both NKT and mucosal-associated T-cells is expressed in CNS tumours in contrast to MS plaques	P 520
		A. Peterfalvi, E. Gomori, T. Magyarlaki, J. Pal, L. Szereday, Z. Illes (Pecs, HUN)
		Osteopontin plasma levels in relapsing-remitting multiple sclerosis patients are related to bone-specific markers	P 521
		M.H.J. Vogt, D.A.M. Heijnen, E. Iacobaeus, C.E. Teunissen, L. Brundin, L. Nagelkerken, C. Polman, C.D. Dijkstra (Amsterdam, NL; Stockholm, S; Leiden, NL)
		Are TWEAK and DcR3 molecular targets for the treatment of multiple sclerosis?	P 522
		S. Killian, A.M. Mueller, X. Pedre, A. Steinbrecher (Regensburg, D)
		Expression of a membrane-bound and a soluble form of TREM-2 in the central nervous system: association with multiple sclerosis	P 523
		L. Piccio, C. Buonsanti, M. Cella, J. Rinker, C. Fenoglio, D. Galimberti, E Scarpini, P. Panina-Bordignon, M. Colonna, A.H. Cross (St Louis, USA; Milan, I)
		TRAF2 gene expression is clearly elevated in relapsing-remitting multiple sclerosis	P 524
		R. Reuß, A. Mirau, M. Mistarz, K. Retzlaff, S. Pohle, P. Oschmann (Giessen, D)
		CD4+CD25+FoxP3+ regulatory T-cells and T-bet expression in CD4+ T-cells from relapsing-remitting multiple sclerosis patients	P 525
		G. Frisullo, V. Nociti, R. Iorio, A.K. Patanella, M. Caggiula, C. Sancricca, M. Mirabella, P.A. Tonali, A.P. Batocchi (Rome, I)
		B-cells
		B cells in MS patients exhibit an abnormal effector cytokine profile under Th1 environment	P 526
		M. Niino, C. Ghorayeb, M. Duddy, F. Adatia, S. Hebert, A. Bar-Or (Sapporo, JP; Montreal, CAN)
		Increased concentrations of the B-cell chemokine CXCL13 correlates with intrathecal inflammation and B cell recruitment to the CSF in multiple sclerosis	P 527
		P. Mataji, P.S. Sørensen, J.L. Frederiksen, F. Sellebjerg (Copenhagen, Glostrup, DK)
		Plasmablasts are the predominant clonally expanded antibody producing cells in multiple sclerosis cerebrospinal fluid	P 528
		K. Winges, G. Owens, J. Bennett, X. Yu, J. Corboy, D. Gilden (Denver, USA)
		Oligoclonal IgM bands against myelin lipids identify two groups of MS patients with heterogeneous CSF cell profiles	P 529
		L.M. Villar, M. Espiño, E. Roldan, M.C. Sadaba, J. Gomez-Rial, N. Garcia-Barragan, M. Diaz-Sanchez, P. Gonzalez-Porque, J.C. Alvarez-Cermeño (Madrid, E)
		Effect of natalizumab on B lymphocytes in patients with multiple sclerosis	P 530
		N. Putzki, M. Kumar, H. Grosse-Wilde, E. Kreuzfelder (Essen, D)
		NMO
		NMO-IgGs specifically bind primary human fetal astrocytes	P 531
		T. Vincent, A. Roth, R. Cayrol, D.R. Colman, A. Bar-Or, A. Prat, J.P. Antel (Montreal, CAN; Montpellier, F)
		Frequency of Aqp4-Ab in patients with neuromyelitis optica (Devic's syndrome) is higher than predicted by NMO-IgG testing	P 532
		S. Jarius, P. Waters, M.I. Leite, R. Geraldes, E. Littleton, J. Palace, D. Beeson, A. Vincent (Oxford, UK; Lisbon, P)
		NMO-IgG/Aqp4-Ab belongs to the IgG1 subclass and activates complement in vitro	P 533
		S. Jarius, S. Jacob, M.I. Leite, P. Waters, A. Vincent (Oxford, UK)
		Neuromyelitis optica and longitudinally extensive transverse myelitis following thymectomy for myasthenia gravis	P 534
		S. Jarius, F. Paul, A. Martins da Silva, M.I. Leite, P. Waters, E. Littleton, D. Franciotta, J. Palace, F. Zipp, A. Vincent (Oxford, UK; Berlin, D; Porto, P; Pavia, I)
		Clinical, MRI and laboratory findings in a cohort of French Devic’s neuromyelitis optica: comparison between NMO-IgG seropositive and seronegative patients	P 535
		R. Marignier, J. De Seze, S. Vukusic, F. Durand-Dubief, H. Zephir, P. Vermersch, F. Blanc, G. Castelnovo, P. Labauge, C. Lebrun, G. Cavillon, J. Honnorat, C. Confavreux (Lyon, Strasbourg, Lille, Nimes, Nice, F)
		NMO-IgG predicts the outcome of recurrent optic neuritis	P 536
		M. Matiello, A. Jacob, S. Pittock, V. Lennon, C. Lucchinetti, D. Wingerchuk, B. Weinshenker (Rochester, USA)
		Clinical characteristics of anti-aquaporin-4 antibody positive opticospinal multiple sclerosis patients: frequent association of brain lesions on MRI and ineffective outcome of interferon beta 1b therapy	P 537
		T. Okamoto, M. Ogawa, Y. Lin, T. Yamamoto, M. Yoshimura, Y. Aoki, Y. Saitoh, F. Endo, M. Murata, W. Sato, T. Aranami, T. Yamamura, R. Takano, T. Takahashi (Tokyo, Sendai, Yonezawa, JP)
		NMO-IgG serology in chronic relapsing inflammatory optic neuropathy	P 538
		A. Petzold, S. Pittock, V. Lennon, A. Wanijha, R. Caulkin, B. Weinshenker, G. Plant (London, UK; Rochester, USA)
		Glatiramer acetate
		Down-regulation of Toll-receptor mediated chemotaxis factors by glatiramer acetate and migration of regulatory T-cells into CNS	P 539
		S. Begum-Haque, A. Sharma, D. Foureau, A. Haque, L. Kasper (Lebanon, USA)
		Down-regulation of IL-17 and IL-6 within the CNS by glatiramer acetate in a murine EAE model	P 540
		S. Begum-Haque, A. Sharma, D. Foureau, A. Haque, L. Kasper (Lebanon, USA)
		Glatiramer acetate induces in vivo expansion of a population of immunosuppressive CD4+ T-cells expressing B and T lymphocyte attenuator	P 541
		A. Ryzhkova, M. Scholl, A. Melms, F. Bischof (Tubingen, D)
		Inteferon beta
		Analysis of chemokine receptors associated with the clinical response to interferon beta therapy in multiple sclerosis	P 542
		C. López, M. Zayat, J. Río, C. Nos, F. Deisenhammer, C. Espejo, X. Montalban, M. Comabella (Barcelona, E; Innsbruck, A)
		Dopaminergic modulation of regulatory T-lymphocyte function in multiple sclerosis patients undergoing interferon beta treatment	P 543
		M. Zaffaroni, M. Cosentino, M. Giorelli, F. Marino, M. Ferrari, E. Carcano, C. Pica, A. Lia, R. Bombelli, E. Rasini, F. Saporiti, A. Rizzo, S. Baldini, A. Ghezzi, M. Trojano, S. Lecchini, G. Comi (Gallarate, Varese, Bari, Milan, I)
		Trail expression rates of multiple sclerosis patients relation with interferon therapy	P 544
		A. Kurne, H. Canpinar, O.F. Aydin, G. Sayat, D. Güç, R. Karabudak (Ankara, Samsun, TR)
		Polarisation of nkt cells to a th17 phenotype following treatment with high-dose interferon beta	P 545
		R. DuPont, L. Minns, L. Kasper (Lebanon, USA)
		Innate and adaptive anti-viral immune responses in multiple sclerosis patients treated with interferon beta	P 546
		T. Christensen (Aarhus, DK)
		Interferon beta modulates Toll-like receptor ligand induced pro-inflammatory cytokine production by human macrophages and dendritic cells	P 547
		C. Sweeney, L. Costelloe, N. Tubridy, K.H.G. Mills, J.M. Fletcher (Dublin, IRL)
		IL-17 mRNA expression in PBMNCs from MS patients increases after 1-year of IFN beta-1b treatment	P 548
		J. Drulovic, D. Popadic, J. Kostic, T. Pekmezovic, M. Mostarica Stojkovic (Belgrade, RS)
		Increased susceptibility to fas-induced apoptosis by activated CD4+CCR5+ T-cells from multiple sclerosis patients	P 549
		E. Julià, N. Téllez, C. Tur, X. Montalban, M. Comabella (Barcelona, E)

Saturday, October 13, 200715:30 - 17:00

Poster topic 13

Immunology 2

Saturday, October 13, 2007
15:30 - 17:00